Central giant cell granuloma (CGCG) is a non-neoplasic lesion of unknown etiology.
This lesion was initially described by Jaffe in 1953 as a "reparative" reaction, but this term was abandoned when it was proven to be more destructive than reparative in nature.
The World Health Organization has defined it as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of hemorrhage, aggregations of multinucleated giant cells and occasionally trabeculae of woven bone. CGCG accounts for less than 7 % of all benign lesions of jaws.
There is predilection in patients younger than 30 years and it occurs more frequently in females, in the anterior region of mandible.
Giant cell lesions of jaws demonstrate variable clinical behavior and radiological changes. The lesions varies from a slow growing painless swelling to a rapidly aggressive lesion that presents with pain, cortical perforation, root displacement or root resorption.
Radiographic findings are diverse, ranging from small apical lesions to large multilocular lesions, with varying degrees of expansion. This radiographic appearance is not pathognomonic and may be confused with several other lesions of jaws.
°International journal of odontostomatology
°Central Giant Cell Granuloma in a Child - Case Report
°Soukayna Bahbah / Saloua Dghoughi / Hakima Chhoul / Wafaa El Wady